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Fig. 1 | Orphanet Journal of Rare Diseases

Fig. 1

From: Chronic myelomonocytic leukemia as a cause of fatal uncontrolled inflammation in familial Mediterranean fever

Fig. 1

Morphological features of CMML in patient #9 and cytokine profiles in patients and controls. a Bone marrow smears from patient #9 with CMML and FMF (see Additional file 1: Table S1) (I) showing dysgranulopoiesis (hypogranular cytoplasm and Döhle bodies indicated with the arrow) at t = 0; (II) dysplastic binucleate erythroblasts at the stage of myelodysplastic syndrome (t = 0); (III) persistence of myeloid dysplasia (indicated with an arrow) at t = 6; (IV) appearance of a monocytosis (solid arrow) with excess of blasts (dashed arrow) when progression to CMML at t = 6. b Blood monocyte counts and serum CRP levels at the indicated time points in patient #9. t = 0 is first time the patient complained about symptoms worsening. The solid black arrow indicates the time of CMML diagnosis and the dashed arrow indicates when plasma was drawn for cytokine measurements. c IL-6 levels in plasma samples from patient #9, FMF patients and apparently healthy controls, as quantified by ELISA. d IL-18 levels in plasma samples from patient #9, FMF patients and apparently healthy controls, as quantified by ELISA

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