Fig. 2

Categorical change from baseline DS3 severity status 1, 2, and 5 years after treatment initiated. Purple color indicates patients for whom data was unavailable for the year evaluated. Mean (SD) ERT doses and range in units/kg body weight/q 2 weeks are shown beneath the pie charts. Each sub-group includes a few patients in whom treatment was interrupted during an evaluation period and some patients were treated at very low doses