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Table 2 Bivariate and multivariate analyses of D0 biological parameters associated with %DRBC change under HU

From: Biological parameters predictive of percent dense red blood cell decrease under hydroxyurea

  Bivariate analysis Multivariate analysis*
Parameter r p value β-coefficient p value
%DRBCs −0.863 <0.0001 −0.885 <0.0001
WBCs (G/L) −0.257 0.068
MCV (fl) −0.018 0.902
MCHC (g/dL) −0.485 0.0004 0.668 0.404
MCH (pg) −0.140 0.332
Hb (g/dL) 0.097 0.501
%HbF 0.099 0.484
Reticulocytes (G/L) −0.437 0.002 −0.004 0.703
Platelets (G/L) 0.200 0.159
Total bilirubin (μmol/L) −0.426 0.002 0.034 0.285
ALT (IU/L) −0.144 0.310
AST (IU/L) −0.419 0.002 −0.023 0.285
LDH (IU/L) −0.324 0.020 −0.001 0.801
  1. *Model also adjusted for age and WBC count: r2 = 0.768.
  2. Numerical data in bold indicate significant correlation with %DRBC decrease.