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Table 5 Relative risk of aivc associated with hereditary coagulation defects and anatomic malformations

From: Elevated risk of thrombophilia in agenesis of the vena cava as a factor for deep vein thrombosis

Risk factors in AIVC Univariate analysis Multivariate analysis
Relative risk (95% CI) P value Relative risk (95% CI) P value
Age (years) 27.98 (35.65-41.17) <0.0001** 22.31 (32.62-39.89) <0.0001
Gender (male) 3.274 (2.064-5.192) <0.0001* 5.789 (3.131-10.701) <0.0001
Factor V Leiden 3.913 (1.721-8.895) 0.001* 4.890 (1.647-7.517) <0.0001
MTHFR gene mutation 3.354 (1.385-8.123) 0.005* 2.132 (1.016-7.072) 0.005
Homocysteinemia 6.641 (2.243-19.659) <0.0001* 6.916 (2.544-19.814) <0.0001
Aplasia of right kidney 58.4†† 0.002* 64.8†† 0.002
Hypoplasia of left kidney 36.1†† 0.059* 46.7†† 0.042
Right sided DVT 1.707 (0.999-2.918) 0.049* 1.663 (1.025-3.267) 0.049
Both sided DVT 2.019 (1.298-3.141) 0.002* 2.003 (1.305-3.349) 0.002
  1. DVT deep vein thrombosis. AIVC inferior vena cava agenesia. MTHFR 5,10-methylenetetrahydrofolate reductase.
  2. *Univariate analyses were performed with the use of the chi-square test. Multivariate analyses were performed with the use of the stepwise logistic-regression procedure. CI denotes confidence interval.
  3. **Univariate analyses were performed with the use of the T-test. Multivariate analyses were performed with the use of the stepwise logistic-regression procedure. CI denotes confidence interval.
  4. All stepwise logistic-regression analyses were performed with the following variables: presence of factor-V-Leiden; presence of prothrombin-gene-mutation; presence of the MTHFR-gene-mutation; hyperhomocysteinemia; presence of Lupus anticoagulant; aplasia of the right kidney; hypoplasia of the left kidney; polysplenia; right sided DVT; both sided DVT; age; gender; the P values indicate the significance of each risk factor independently.
  5. ††Because no patient with NoAIVC had this combined defect, the estimated relative risk was calculated on the basis of the probability of a combined defect in these patients. For this reason, no confidence interval is given.