Risk factors in AIVC

Univariate analysis

Multivariate analysis
^{†}


Relative risk (95% CI)

P value

Relative risk (95% CI)

P value


Age (years)

27.98 (35.6541.17)

<0.0001**

22.31 (32.6239.89)

<0.0001

Gender (male)

3.274 (2.0645.192)

<0.0001*

5.789 (3.13110.701)

<0.0001

Factor V Leiden

3.913 (1.7218.895)

0.001*

4.890 (1.6477.517)

<0.0001

MTHFR gene mutation

3.354 (1.3858.123)

0.005*

2.132 (1.0167.072)

0.005

Homocysteinemia

6.641 (2.24319.659)

<0.0001*

6.916 (2.54419.814)

<0.0001

Aplasia of right kidney

58.4^{††}

0.002*

64.8^{††}

0.002

Hypoplasia of left kidney

36.1^{††}

0.059*

46.7^{††}

0.042

Right sided DVT

1.707 (0.9992.918)

0.049*

1.663 (1.0253.267)

0.049

Both sided DVT

2.019 (1.2983.141)

0.002*

2.003 (1.3053.349)

0.002


DVT deep vein thrombosis. AIVC inferior vena cava agenesia. MTHFR 5,10methylenetetrahydrofolate reductase.
 *Univariate analyses were performed with the use of the chisquare test. Multivariate analyses were performed with the use of the stepwise logisticregression procedure. CI denotes confidence interval.
 **Univariate analyses were performed with the use of the Ttest. Multivariate analyses were performed with the use of the stepwise logisticregression procedure. CI denotes confidence interval.

^{†}All stepwise logisticregression analyses were performed with the following variables: presence of factorVLeiden; presence of prothrombingenemutation; presence of the MTHFRgenemutation; hyperhomocysteinemia; presence of Lupus anticoagulant; aplasia of the right kidney; hypoplasia of the left kidney; polysplenia; right sided DVT; both sided DVT; age; gender; the P values indicate the significance of each risk factor independently.

^{††}Because no patient with NoAIVC had this combined defect, the estimated relative risk was calculated on the basis of the probability of a combined defect in these patients. For this reason, no confidence interval is given.