Table 3 Neuroimaging (MRI or CT scan) data before and after the initiation of folinic acid therapy and clinical outcome
Cases | Time between images (years) | Atrophy | Abnormal high signal on T2-weighted images | Clinical outcome NPMDS* Sections I-III Pre/Post | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
Age at neuroimaging before therapy | Cerebral | Cerebellar | Cerebrum subcortical | Brain stem | Basal ganglia | Thalamus | Cerebellum | |||
Pre/Post | Pre/Post | Pre/Post | Pre/Post | Pre/Post | Pre/Post | Pre/Post | ||||
1 | 8 | 0.7 | + / ++ | +/+ | +/+ | +/+ | 31/40 | |||
2 | 11 | 2.7 | +/ ++ | +/+ | +/+ | 7/14 | ||||
3 | 17 | 3 | −/+ | + | +/+ | −/+ | + | −/+ | 26/54** | |
4* | 14 | 3 | −/+ | −/+ | +/+ | −/+ | 29/67** | |||
5 | + | + | + | + | + | + | Unknown | |||
6 | 13 | 2 | +/+ | +/+ | −/+ | 17/22 | ||||
7 | + | + | + | + | Unknown | |||||
8 | 8 | 2 | +/ - | 20/24 | ||||||