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Table 1 Patients’ previous pharmacological therapies

From: Treatment of motor and behavioural symptoms in three Lesch-Nyhan patients with intrathecal baclofen

Patient Remote therapeutic history Previous therapy before ITB placement
1 Trihexyphenidyl 4 mg x3/day Started in 2006
Discontinued in 2010
S-adenosyl methionine 400 mg x4/day Started in 2000
Initial efficacy, progressively lost
Discontinued 24/04/2013
2 Risperidone 6 mg /day Started in 1998
Discontinued in 2011
Levetiracetam 250 mg x3/day Started in 2002
No efficacy
Weaned from 03/01/2014, discontinued 20/02/2014
Clonazepam 1 mg /day Started in 2002
Partial efficacy on spasticity
Weaned from 12/02/2014, discontinued 21/02/2014
Sertraline 50 mg /day Started in 2002
Scarce efficacy
Weaned from 08/02/2014, discontinued 22/02/2014
Zopiclone 7.5 mg /day Started in 2002
Good efficacy on sleep improvement
Weaned from 12/02/2014, discontinued 21/02/2014
3 Enzyme replacement therapy Intrathecal infusion of leukocytes (2/month) Started in 1996
Discontinued in 2010
Gabapentin 400 mg x4/day Started in May, 2013
No efficacy
Weaned from 23/01/2014, discontinued 15/03/2014
Intrathecal infusion of mesenchymal stem cells Single administration in 2012