Table 1 Patients’ previous pharmacological therapies
From: Treatment of motor and behavioural symptoms in three Lesch-Nyhan patients with intrathecal baclofen
Patient | Remote therapeutic history | Previous therapy before ITB placement | ||||
|---|---|---|---|---|---|---|
1 | Trihexyphenidyl | 4 mg x3/day | Started in 2006 Discontinued in 2010 | S-adenosyl methionine | 400 mg x4/day | Started in 2000 |
Initial efficacy, progressively lost | ||||||
Discontinued 24/04/2013 | ||||||
2 | Risperidone | 6 mg /day | Started in 1998 Discontinued in 2011 | Levetiracetam | 250 mg x3/day | Started in 2002 |
No efficacy | ||||||
Weaned from 03/01/2014, discontinued 20/02/2014 | ||||||
Clonazepam | 1 mg /day | Started in 2002 | ||||
Partial efficacy on spasticity | ||||||
Weaned from 12/02/2014, discontinued 21/02/2014 | ||||||
Sertraline | 50 mg /day | Started in 2002 | ||||
Scarce efficacy | ||||||
Weaned from 08/02/2014, discontinued 22/02/2014 | ||||||
Zopiclone | 7.5 mg /day | Started in 2002 | ||||
Good efficacy on sleep improvement | ||||||
Weaned from 12/02/2014, discontinued 21/02/2014 | ||||||
3 | Enzyme replacement therapy | Intrathecal infusion of leukocytes (2/month) | Started in 1996 Discontinued in 2010 | Gabapentin | 400 mg x4/day | Started in May, 2013 |
No efficacy | ||||||
Weaned from 23/01/2014, discontinued 15/03/2014 | ||||||
Intrathecal infusion of mesenchymal stem cells | Single administration in 2012 | |||||