Skip to main content

Table 1 Comparison of the virilizing adverse effects of AAs among different studies

From: Frequency of the virilising effects of attenuated androgens reported by women with hereditary angioedema

  Gelfand [ [7]] Zurlo [ [8]] Cicardi [ [9]] Sloane [ [10]] Bork [ [11]] Our study population
Patients Controls
N° of patients 5 60 28 (D + S) 13 (S) 51/118* 31 41
MENSTRUAL DISTURBANCES 100% 79% 50% (D)/ 18% (S) 23% 76% 26% 38%
ALTERED LIBIDO   10%   8% 3%* 13% 22%
VOICE CHANGE   8%   8% 14%* 19% 10%
HAIR GROWTH   12%    19* 42% 37%
CLITORIS ENLARGEMENT      12% 3% 0%
INCREASED MUSCLE MASS   2%    3%* 13% 7%
BREAST SIZE      12% 16% n.a.#
ACNE/OILY SKIN   8%   8% 9* 19% 12%
WEIGHT GAIN 100% 60% 28% (D)/17% (S) 1% 42%* 39% 59%
WATER RETENTION   2%     6% 29%
HAIR LOSS   18%     19% 27%
PSYCHOLOGICAL ABNORMALITIES   2%   0% 11%* 16% 46%
Discontinuation/continuation of danazol therapy Continued 16% discontinued The vast majority of patients continued therapy No interruption of stanozolol therapy No interruption of stanozolol therapy No interruption of danazol therapy  
  1. Although we would have preferred specifying the absolute numbers of patients, this was not feasible, because not all the authors provided this information. Therefore, all values are expressed as percentages, for the sake of comparability. References are reported in brackets.
  2. D = danazol, S = stanazolol, * = total HAE population (The properties were evaluated both in males and in females),  = p < 0.05, #n.a = Half of the women did not answer this one, or gave information on the elasticity of their breasts.