Frequency of the virilising effects of attenuated androgens reported by women with hereditary angioedema

Table 1 Comparison of the virilizing adverse effects of AAs among different studies

	Gelfand [ [7]]	Zurlo [ [8]]	Cicardi [ [9]]	Sloane [ [10]]	Bork [ [11]]	Our study population
	Gelfand [ [7]]	Zurlo [ [8]]	Cicardi [ [9]]	Sloane [ [10]]	Bork [ [11]]	Patients	Controls
N° of patients	5	60	28 (D + S)	13 (S)	51/118*	31	41
MENSTRUAL DISTURBANCES	100%	79%	50% (D)/ 18% (S)	23%	76%	26%	38%
ALTERED LIBIDO		10%		8%	3%*	13%	22%
VOICE CHANGE		8%		8%	14%*	19%	10%
HAIR GROWTH		12%			19*	42%	37%
CLITORIS ENLARGEMENT					12%	3%	0%
INCREASED MUSCLE MASS		2%			3%*	13%	7%
BREAST SIZE					12%	16%	n.a.^#
ACNE/OILY SKIN		8%		8%	9*	19%	12%
WEIGHT GAIN	100%	60%	28% (D)/17% (S)	1%	42%*	39%	59%
WATER RETENTION		2%				6%	29%^†
HAIR LOSS		18%				19%	27%
PSYCHOLOGICAL ABNORMALITIES		2%		0%	11%*	16%	46%^†
Discontinuation/continuation of danazol therapy	Continued	16% discontinued	The vast majority of patients continued therapy	No interruption of stanozolol therapy	No interruption of stanozolol therapy	No interruption of danazol therapy

Although we would have preferred specifying the absolute numbers of patients, this was not feasible, because not all the authors provided this information. Therefore, all values are expressed as percentages, for the sake of comparability. References are reported in brackets.
D = danazol, S = stanazolol, * = total HAE population (The properties were evaluated both in males and in females), ^† = p < 0.05, ^#n.a = Half of the women did not answer this one, or gave information on the elasticity of their breasts.

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