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Table 3 Comparison of the Antibacterial Activity of Cysteamine and Tobramycin in Artificial Sputum Medium and under standard CLSI conditions

From: Cysteamine (Lynovex®), a novel mucoactive antimicrobial & antibiofilm agent for the treatment of cystic fibrosis

  Mueller Hinton Broth MIC 100(μg/ml) Artificial Sputum Medium MIC 100(μg/ml)
Isolate Cysteamine Tobramycin Cysteamine Tobramycin
P. aeruginosa PAO1 250 1 500 4
P. aeruginosa DSMZ1128 250 1 250 2
P. aeruginosa DSMZ1299 250 1 250 1
P. aeruginosa ATCC27853 250 1 500 2
  1. Data represents the mean MIC100 (μg/ml) of triplicate samples from triplicate experiments. MICs were determined using the broth microdilution procedure from CLSI Approved Standard M07-A9 [18], with artificial sputum medium substituted for MH broth as appropriate. Data represents the mean MIC100 (μg/ml) of triplicate samples from triplicate experiments.