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Table 3 Comparison of the Antibacterial Activity of Cysteamine and Tobramycin in Artificial Sputum Medium and under standard CLSI conditions

From: Cysteamine (Lynovex®), a novel mucoactive antimicrobial & antibiofilm agent for the treatment of cystic fibrosis

 

Mueller Hinton Broth MIC 100(μg/ml)

Artificial Sputum Medium MIC 100(μg/ml)

Isolate

Cysteamine

Tobramycin

Cysteamine

Tobramycin

P. aeruginosa PAO1

250

1

500

4

P. aeruginosa DSMZ1128

250

1

250

2

P. aeruginosa DSMZ1299

250

1

250

1

P. aeruginosa ATCC27853

250

1

500

2

  1. Data represents the mean MIC100 (μg/ml) of triplicate samples from triplicate experiments. MICs were determined using the broth microdilution procedure from CLSI Approved Standard M07-A9 [18], with artificial sputum medium substituted for MH broth as appropriate. Data represents the mean MIC100 (μg/ml) of triplicate samples from triplicate experiments.
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172