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Table 2 Analysis of the Fractional Inhibitory Concentration Index (FICI) of Cysteamine with Cystic Fibrosis-relevant Antibiotics versus P. aeruginosa

From: Cysteamine (Lynovex®), a novel mucoactive antimicrobial & antibiofilm agent for the treatment of cystic fibrosis

  Tobramycin Ciprofloxacin Colistin Gentamicin
Strain Syn Add Ind Syn Add Ind Syn Add Ind Syn Add Ind
PAO1 6 5 0 0 3 5 3 4 4 1 5 0
Pa14 0 7 0 0 2 5 5 7 0 0 5 0
Pa058 0 8 0 0 11 1 0 6 4 0 6 0
57388A 2 5 0 0 2 1 2 6 0 1 6 0
57388D 4 4 0 0 4 1 2 7 0 1 5 0
  1. Numbers in the table indicate the number of replicates demonstrating these effects. Syn = synergy, Add = Additive, Ind = Indifferent. No antagonism was observed for any of the cysteamine-antibiotic combinations. P. aeruginosa Pa14 is colistin resistant, P. aeruginosa Pa058 is ciprofloxacin resistant, P. aeruginosa 57388A is colistin and tobramycin resistant and P. aeruginosa 57388A is ciprofloxacin and tobramycin resistant. P. aeruginosa PAO1 is sensitive to all antibiotics tested.