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Table 2 Levels of evidence and grading of recommendations (National Health and Medical Research Council 1999 [19])

From: Consensus clinical management guidelines for Friedreich ataxia

I Evidence obtained from a systematic review of all relevant randomized controlled trials
II Evidence obtained from at least one properly designed randomized controlled trial
III-1 Evidence obtained from well-designed pseudo-randomized controlled trials (alterative allocation or some other method)
III-2 Evidence obtained from comparative studies with concurrent controls and allocation not randomized (cohort studies), case–control studies, or interrupted time series with a control group
III-3 Evidence obtained from comparative studies with historical control, two or more single-arm studies, or interrupted time series without a parallel control group
IV Evidence obtained from case series, either post-test or pre-test and post-test.