Magnetic resonance imaging (MRI) and small fiber neuropathy diagnosis by PGP9.5 immunofluorescence. (A-C) Fluid attenuated inversion recovery (FLAIR) MRI of patient #1 showed multiple, punctuated white matter lesions from periventricular (yellow arrows and circles) to subcortical (red arrows and circles) without gadolinium enhancement. (D) Skin biopsy analysis of patient #2 showed the reduction of the small epidermal nerve fibers (arrow). Scale bar = 20 μm. (E-F). The number of focal axonal swellings (arrows) larger than 1.5 μm was increased. Scale bar = 10 μm. (G) Skin biopsy of a healthy control. Scale bar = 30 μm.