Rare inborn errors of metabolism with movement disorders: a case study to evaluate the impact upon quality of life and adaptive functioning

Table 3 Comparison of HRQOL scores between patients with a less severe and more severe movement disorder

Severity of movement disorder	Minimal to moderate *n =* 14	Marked to severe n = 9	U-value	Z-value	p -value*
Severity of movement disorder	Mean value (SD)	Mean value (SD)	U-value	Z-value	p -value*
Total score	59.00 (17.92)	33.67 (19.55)	22.00	-2.60	0.009
Physical functioning	49.64 (22.28)	20.44 (18.08)	18.00	-2.84	0.003
Emotional functioning	69.57 (20.33)	54.44 (26.75)	40.00	-1.45	0.159
Social functioning	59.86 (26.24)	31.67 (27.04)	48.00	-2.21	0.028
School functioning	57.36 (29.27)	39.22 (35.52)	45.50	-1.11	0.277

HRQOL scores were measured on the PedsQL 4.0 Generic Core Scales. The total cohort was divided in two groups based on the severity of their movement disorder, determined by the expert panel.
HRQOL Health-related quality of life, SD Standard deviation; *significance level after Bonferroni-Holm correction for multiple comparisons.
Bold text: statistically significant.

ISSN: 1750-1172