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Table 1 Pathologic and genetic features and classification of EBV + T/NK-cell lymphoproliferative disease

From: Prognostic implication of morphology, cyclinE2 and proliferation in EBV-associated T/NK lymphoproliferative disease in non-immunocompromised hosts

No Diagnosis* Ohshima category** Histo CD4 CD8 CD56 TCR αβ TCR γδ TCR PCR Cell of origin BM karyotype
1 CAEBV A1 P - - - - - PC TCR silent vs NK N
2 CAEBV A1 P - + - + - PC T N
3 CAEBV A1 P - + + - - PC TCR silent vs NK N
4 STLPDC A2 P - + - + - MC T N
5 STLPDC A2 P - + - - - MC T N
6 STLPDC A2 P - + - - - MC T N
7 STLPDC A2 P + - + Focal + - MC T N
8 CAEBV vs STLPDC A1 or A2 P NA NA + NA NA NA NA NA
9 CAEBV vs STLPDC A1 or A2 P - + - NA NA NA NA NA
10 CAEBV vs STLPDC A1 or A2 P + + - NA NA NA NA NA
11 CAEBV vs STLPDC A1 or A2 P NA NA - NA NA NA NA NA
12 STLPDC A3 M - + + Focal + - MC T Abn
13 STLPDC A3 M - + - + - MC T N
14 STLPDC B M - + + + - MC T Abn
15 STLPDC B M - + - - - MC T Abn
16 STLPDC B M + - - Focal + - PC favour T Abn
17 STLPDC B M - + - + - MC T N
18 STLPDC B M - + - + - MC T Mosaic
19 STLPDC B M - + - + - NA T N
20 STLPDC B M + - - + NA PC T Abn
21 STLPDC B M - - - NA NA NA NA NA
22 favour STLPDC A3 or B M - - + + - NA T NA
  1. Abbreviations: Histo histology, M monomorphic, P polymorphic, TCR clonality for T-Cell Receptor Gamma gene by PCR, MC monoclonal, PC polyclonal, Abn abnormal, N normal, NA not available, OS overall survival, BM bone marrow, CAEBV chronic active EBV infection of T-NK type, STLPDC systemic EBV + T cell lymphoproliferative disorder of childhood, EBV + TLPD EBV-positive T cell lymphoproliferative disorder.
  2. EBV terminal repeats analysis revealed monoclonality.
  3. *Based on WHO classification and recommendation from NIH consensus meeting in 2008 [12].
  4. **Based on categorization of EBV + T/NK lymphoproliferative disorders in children by Ohshima et al. [13].