Prognostic implication of morphology, cyclinE2 and proliferation in EBV-associated T/NK lymphoproliferative disease in non-immunocompromised hosts

Table 1 Pathologic and genetic features and classification of EBV + T/NK-cell lymphoproliferative disease

No	Diagnosis*	Ohshima category**	Histo	CD4	CD8	CD56	TCR αβ	TCR γδ	TCR PCR	Cell of origin	BM karyotype
1	CAEBV	A1	P	-	-	-	-	-	PC	TCR silent vs NK	N
2	CAEBV	A1	P	-	+	-	+	-	PC	T	N
3	CAEBV	A1	P	-	+	+	-	-	PC	TCR silent vs NK	N
4	STLPDC	A2	P	-	+	-	+	-	MC	T	N
5	STLPDC	A2	P	-	+	-	-	-	MC	T	N
6	STLPDC	A2	P	-	+	-	-	-	MC	T	N
7	STLPDC	A2	P	+	-	+	Focal +	-	MC	T	N
8	CAEBV vs STLPDC	A1 or A2	P	NA	NA	+	NA	NA	NA	NA	NA
9	CAEBV vs STLPDC	A1 or A2	P	-	+	-	NA	NA	NA	NA	NA
10	CAEBV vs STLPDC	A1 or A2	P	+	+	-	NA	NA	NA	NA	NA
11	CAEBV vs STLPDC	A1 or A2	P	NA	NA	-	NA	NA	NA	NA	NA
12	STLPDC	A3	M	-	+	+	Focal +	-	MC	T	Abn
13	STLPDC	A3	M	-	+	-	+	-	MC	T	N
14	STLPDC	B	M	-	+	+	+	-	MC	T	Abn
15	STLPDC	B	M	-	+	-	-	-	MC	T	Abn
16	STLPDC	B	M	+	-	-	Focal +	-	PC	favour T	Abn
17	STLPDC	B	M	-	+	-	+	-	MC	T	N
18	STLPDC	B	M	-	+	-	+	-	MC	T	Mosaic
19	STLPDC	B	M	-	+	-	+	-	NA	T	N
20	STLPDC	B	M	+	-	-	+	NA	PC	T	Abn
21	STLPDC	B	M	-	-	-	NA	NA	NA^‡	NA	NA
22	favour STLPDC	A3 or B	M	-	-	+	+	-	NA	T	NA

Abbreviations: Histo histology, M monomorphic, P polymorphic, TCR clonality for T-Cell Receptor Gamma gene by PCR, MC monoclonal, PC polyclonal, Abn abnormal, N normal, NA not available, OS overall survival, BM bone marrow, CAEBV chronic active EBV infection of T-NK type, STLPDC systemic EBV + T cell lymphoproliferative disorder of childhood, EBV + TLPD EBV-positive T cell lymphoproliferative disorder.
^‡EBV terminal repeats analysis revealed monoclonality.
*Based on WHO classification and recommendation from NIH consensus meeting in 2008 [12].
**Based on categorization of EBV + T/NK lymphoproliferative disorders in children by Ohshima et al. [13].

ISSN: 1750-1172