Table 2 Induction of amenorrhea

1.

GnRH agonist (3.75 mg/month subcutaneous leuprolide acetate, in general), enabling

a. induction of amenorrhea

b. “parenteral” contraceptive effect effective even in patients with vomiting

c. possible anti-apoptotic, protective effect on the follicles, observed in animal studies but not yet in women.

2.

In order to avoid flare-ups, it is recommended to prescribe

a. a contraceptive pill 10 to 15 days after the agonist injection

b. or a macroprogestin for the first month.