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Table 2 SPTL patients show differences in the expression of selected genes compared to controls

From: Molecular characterization of subcutaneous panniculitis-like T-cell lymphoma reveals upregulation of immunosuppression- and autoimmunity-associated genes

Gene Normal fat 1 Combined controls 2 Inflammatory EN 3 DNA band Gene function
FC p-value FC p-value FC p-value
CXCL10 170.1 <0.01 32.93 0.05 ns ns 4q21.1 chemokine, T-cell trafficking, ligand for CXCR3
GBP5 78.08 <0.01 28.00 0.02 ns ns 1p22.2 GTPase activity, cellular response to interferon-G
IDO1 70.57 <0.01 35.52 <0.01 17.91 0.01 8p12-11 catabolism of tryptophan, suppressor of immune response
IKZF3 63.27 0.05 24.48 0.01 10.98 0.05 17q12 B-cell activation, regulation of lymphocyte differentiation
IGJ 55.37 0.01 36.09 0.01 19.40 0.03 4q13.3 IgA and antigen binding, adaptive immune response,
CXCL9 ns ns 20.25 0.04 ns ns 4q21.1 chemokine, T-cell trafficking, ligand for CXCR3
IL2RB 45.71 <0.01 25.76 <0.01 12.49 0.01 22q12.3 cytokine receptor
CXCL11 41.41 <0.01 17.31 0.01 7.33 0.02 4q21.1 chemokine, T-cell trafficking, ligand for CXCR3
KLRD1 36.53 0.01 28.68 0.01 19.44 0.01 12p13.2 transmembrane receptor activity, innate immune response
CCL5 34.83 <0.01 18.37 0.01 ns ns 17q12 chemokine, T-cell polarization
PRF1 32.69 <0.01 26.15 <0.01 19.86 <0.01 10q22.1 calcium ion binding, cellular defense response,
SLAMF7 28,67 0.01 16.60 <0.01 9.89 0.01 1q23.3 lymphocyte activation
GZMB 22.58 <0.01 22.58 <0.01 18.57 <0.01 14q12 T-cell cytotoxicity
CCR5 25.72 <0.01 10.21 0.01 4.75 <0.01 3p21.31 chemokine receptor
NKG7 23.55 <0.01 17.73 <0.01 13.82 <0.01 19q13.41 integral component of plasma membrane
RASGRP1 20.76 0.03 8.09 0.01 4.10 <0.01 15q14 lymphocyte regulation
APOBEC3G 19.47 <0.01 9.65 <0.01 5.42 <0.01 22q13.1 innate immune response, defense response to virus
KIR2DS4 ns ns ns ns 19,01 0.05 19q13.42 innate immune response
IFNG 17.24 0.01 15.46 0.01 10.45 0.01 12q15 cytokine, immunoregulator
TNFRSF9 15.54 0.02 14.45 0.02 11.57 0.02 1p36.23 receptor, survival and development of T cells
CCL4 12.64 <0.01 8.97 0.01 ns ns 17q12 chemokine, T-cell polarization
TRIM59 9.93 0.01 5.38 0.03 ns ns 3q25.33 negative regulation of I-kappaB kinase/NF-kappaB signaling
CXCR3 9.83 0.04 6.68 <0.01 4.68 0.04 Xq13.1 chemokine receptor, recruitment of inflammatory cells
FASLG 5.00 0.01 5.38 <0.01 6.12 0.01 1q24.3 cytokine activity, T cell apoptotic process
TBX18 0.22 0.05 ns ns ns ns 6q14.3 transcription factor
TBX15 0.13 <0.01 0.19 <0.01 ns ns 1p12 transcription factor
  1. 1SPTL vs. normal subcutaneous fat, 2SPTL vs. combined controls, 3SPTL vs. inflammatory EN, ns = non-significant. FC = Fold Change. See ArrayExpress for all data.
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172