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Table 4 Type of congenital heart defect in sporadic and familial patients with Holt Oram syndrome (N = 48)

From: Holt Oram syndrome: a registry-based study in Europe

Type of CHD Sporadic Familial TOTAL
ASD 13 (34.2%) 5 (50.0%) 18 (37.5%)
VSD 7 (18.4%) 1 (10.0%) 8 (16.7%)
ASD + VSD 2 (5.3%) 2 (20.0%) 4 (8.3%)
Complex 12 (31.6%) - 12 (25%)
Other 4 (10.5%) 2 (20.0%) 6 (12.5%)
TOTAL 38 10 48/61* (78.7% )
  1. *Number of HOS patients with available data on type and frequency of major congenital anomalies.
  2. CHD - congenital heart defect, ASD - atrial septal defect, VSD - ventricular septal defect.