Table 1 Clinical information on 350 patients with late-onset MADD published in the literature
From: Clinical and genetical heterogeneity of late-onset multiple acyl-coenzyme A dehydrogenase deficiency
Sex | Female n = 144, male n = 177, not reported n = 29 |
Identified by newborn screening | 2.0% (7/350) patients |
Identified by family screening | 1.4% (5/350) patients |
Acute symptoms | 33.1% (111/335) of patients |
Chronic symptoms | 85.3% (291/341) of patients |
Acute and chronic symptoms | 20.4% (68/333) of patients |
Mean age at onset of symptoms | 19.2 years (n = 273) |
Mean diagnostic delay | 3.9 years (0-29 years) |
Asymptomatic | 2.6% (9/349) of patients |
Deceased patients | 5.2% (18/349) of patients |
Riboflavin responsiveness | 98.4% (256/260) of patients |