Figure 4

Biomarker responses for a median patient for the final model according to significant covariates for ferritin, chitotriosidase, hemoglobin and platelets. A green line is for non-splenectomized patients and a red line for splenectomized patients. A dotted line is for man and continuous for woman. For platelets, no distinction between man and woman and change is a continuous line. Initial concentration and concentrations at steady state of ERT are indicated, in green for non-splenectomized, red for splenectomized patients, and in orange when no distinction can be made depending on splenectomy. Lines are thin for man and bold for woman. Left: patients <15 years of age. Right: patients > 15 years of age.