Figure 3

Individual fits for two patients of biomarkers versus time during ERT for A) ferritin, B) chitotriosidase, C) hemoglobin and D) platelets for two patients. Top: splenectomized patient with red dots. Bottom: non-splenectomized patient with green dots. The black line corresponds to the curve predicted by the model. Time 0 corresponds to initiation of ERT, vertical gray line. Gray horizontal lines correspond to the limit of usual values: ferritin <250 μg/L, chitotriosidase <100 nmol/mL/h, hemoglobin >12 g/dL, platelet count >150 000/mm³.