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Figure 1 | Orphanet Journal of Rare Diseases

Figure 1

From: Modeling changes in biomarkers in Gaucher disease patients receiving enzyme replacement therapy using a pathophysiological model

Figure 1

Scheme of the effect of Gaucher disease on biomarkers and the effect of ERT. A: Mechanistic pathophysiological model. Plus sign (+) indicates stimulation and minus sign (−) indicates inhibition. C is chitotriosidase produced at a rate of R and removed at a rate of λ B: Simplified model of changes in biomarkers during ERT. Left: biomarkers that decrease during ERT (ferritin, chitotriosidase); right: biomarkers that increase during ERT (hemoglobin, platelets). C0 is initial concentration, k rate of decrease (or increase) and C0r estimated corrected value at steady state of ERT.

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172