Figure 2

Genealogical analysis of cases of pulmonary alveolar proteinosis from La Réunion Island. A. Genealogical network connecting the 32 patients for which a parental consent was obtained to their most recent couple of common ancestors. Each patient (squares for boys and circles for girls) is denoted by his/her identifier. Each couple of ancestors is represented by an octagon of varying size and color according to the number of patients for which they are ancestors (from 1 to 32 as illustrated by the inner scale). The most recent couple of common ancestors (black octagon) married in 1731. Therefore, we can assert that all studied cases for which a consent was obtained are family connected. B. Deepest analysis connecting the 32 patients for which a parental consent was obtained to all their common ancestors. We found 32 couples of ancestors common to all patients (black octagons), each of them being a potential carrier of a genetic factor reponsible of the disease.