Diagrams of the 3D model of ZNF407 tandem finger domains (rainbow colored) and a double-stranded DNA sequence (phosphate backbone in orange and bases as green-to-blue sticks). a: Wild type finger 19-finger 20 linker with p.P1713 and p.E1711 (positions i + 4 and i + 2, respectively). b: Wild type fingers 18 and 19 with linker peptide showing p.S1685 H-bonded to p.E1683. One zinc ion is coordinated by each finger (grey spheres). c: p.S1685W mutant showing the loss of the H-bond to p.E1683.