Table 1 Comparisons of biologic parameters during 25 patients’ sickle-cell disease vaso-occlusive crises (VOC) and at steady state (ST)
From: First evidence of subclinical renal tubular injury during sickle-cell crisis
Parameter | VOC | ST | P value |
|---|---|---|---|
Hemoglobin (g/dL) | 8.3 ± 1.3 | 8.8 ± 1.2 | 0.01 |
White blood-cell count (106/L) | 12216 ± 4599 | 9832 ± 3359 | 0.009 |
Lactate dehydrogenase (IU/L) | 434.8 ± 181.5 | 392.5 ± 213.1 | 0.16 |
Creatinine (μmol/L) | 60.3 ± 16.8 | 57.5 ± 16.1 | 0.24 |
Urea (mmol/L) | 2.2 ± 1.1 | 2.9 ± 1.1 | 0.01 |
Albuminuria (mg/L) | 71.1 ± 259.4 | 139.4 ± 347.0 | 0.14 |
Albuminuria/creatinuria (mg/mmol) | 14.6 ± 47.5 | 18.4 ± 46.9 | 0.38 |
Urine NGAL (ng/mL) | 76.7 ± 76.7 | 28.7 ± 25.7 | 0.007 |
NGAL/creatinuria (mg/mmol) | 17.1 ± 20.7 | 3.9 ± 3.6 | 0.004 |
C-Reactive protein (mg/L) | 54.9 ± 60.5 | 9.1 ± 7.2 | 0.003 |