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Table 1 Atypical psychiatric features which should trigger a search for inborn error of metabolism in patients with schizophrenia

From: Diagnostic and treatment implications of psychosis secondary to treatable metabolic disorders in adults: a systematic review

First level atypical feature (atypical on their own)

Second level atypical features (atypical when associated with first level)

Confusion

Acute onset

Visual hallucinations more important than auditory hallucinations

Early onset

Catatonia

Intellectual Disability

Progressive cognitive decline

Unusual or severe side effects

Treatment resistance

 

Fluctuating schizophrenia core symptoms

 
  1. As the validity and specificity of these atypical psychiatric signs have not yet been validated, they are presented to rise suspicion and suggest clinical and neurological exam prior to further progressive screening.
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172