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Table 4 GI symptoms in relation to age at onset in patients with TTR mutations

From: THAOS: Gastrointestinal manifestations of transthyretin amyloidosis - common complications of a rare disease

Symptom <50 years ≥50 years p value
n = 725 n = 381
Any GI symptom 509 (70.3%) 185 (49.6%) <0.001
Early satiety 243 (33.7%) 48 (12.9%) <0.001
Nausea 157 (21.7%) 32 (8.6%) <0.001
Vomiting 130 (18.0%) 17 (4.6%) <0.001
Constipation 154 (21.3%) 75 (20.2%) 0.685
Diarrhea/constipation 201 (27.8%) 66 (17.8%) <0.001
Diarrhea 164 (22.7%) 53 (14.4%) 0.001
Fecal incontinence 51 (7.0%) 17 (4.6%) 0.112
Unintentional weight loss 270 (37.4%) 76 (20.6%) <0.001
  1. Number of patients, n (%), reporting gastrointestinal (GI) symptoms at enrollment.