Table 4 GI symptoms in relation to age at onset in patients with TTR mutations
Symptom | <50 years | ≥50 years | p value |
|---|---|---|---|
n = 725 | n = 381 | ||
Any GI symptom | 509 (70.3%) | 185 (49.6%) | <0.001 |
Early satiety | 243 (33.7%) | 48 (12.9%) | <0.001 |
Nausea | 157 (21.7%) | 32 (8.6%) | <0.001 |
Vomiting | 130 (18.0%) | 17 (4.6%) | <0.001 |
Constipation | 154 (21.3%) | 75 (20.2%) | 0.685 |
Diarrhea/constipation | 201 (27.8%) | 66 (17.8%) | <0.001 |
Diarrhea | 164 (22.7%) | 53 (14.4%) | 0.001 |
Fecal incontinence | 51 (7.0%) | 17 (4.6%) | 0.112 |
Unintentional weight loss | 270 (37.4%) | 76 (20.6%) | <0.001 |