Impact of gastrointestinal symptoms on HRQoL in patients with TTR mutations. For each gastrointestinal symptom, patients with a given symptom were compared with those without the symptom. In the V30M group, each symptom had a significant negative impact on health-related quality of life (HRQoL), whereas in the non-V30M group, all symptoms except for alternating diarrhea/constipation showed a significant negative impact. The EQ-5D Index Score was used to assess the HRQoL and full health is represented by a score of 1. The TTR V122I, I68L and L111M mutations were excluded from the non-V30M group; p < 0.05 was regarded as statistically significant. Data are presented as box and whisker plots showing median (horizontal line), interquartile range (box), mean (circle) and range of measurements (whisker).