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Table 2 Overview of clinical features throughout the disease course

From: A multicenter study on Leigh syndrome: disease course and predictors of survival

Frequency of affected organs/systems (n = 130)

N

%

Abnormal motor findings

129

99.2

Abnormal ocular findings

79

60.8

Feeding difficulties

59

45.4

Epileptic seizures

51

39.2

Respiratory dysfunction

49

37.7

Mental retardation

48

36.9

Sucking dysfunction

32

24.6

Hearing dysfunction

25

19.2

Cardiac dysfunction

23

17.7

Failure to thrive

21

16.2

Hepatic dysfunction

16

12.3

Microcephaly

15

11.5

Peripheral neuropathy

9

6.9

Renal dysfunction

7

5.4

Haematological dysfunction

2

1.5