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Table 2 Overview of clinical features throughout the disease course

From: A multicenter study on Leigh syndrome: disease course and predictors of survival

Frequency of affected organs/systems (n = 130) N %
Abnormal motor findings 129 99.2
Abnormal ocular findings 79 60.8
Feeding difficulties 59 45.4
Epileptic seizures 51 39.2
Respiratory dysfunction 49 37.7
Mental retardation 48 36.9
Sucking dysfunction 32 24.6
Hearing dysfunction 25 19.2
Cardiac dysfunction 23 17.7
Failure to thrive 21 16.2
Hepatic dysfunction 16 12.3
Microcephaly 15 11.5
Peripheral neuropathy 9 6.9
Renal dysfunction 7 5.4
Haematological dysfunction 2 1.5
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