From: A multicenter study on Leigh syndrome: disease course and predictors of survival
Frequency of affected organs/systems (n = 130) | N | % |
---|---|---|
Abnormal motor findings | 129 | 99.2 |
Abnormal ocular findings | 79 | 60.8 |
Feeding difficulties | 59 | 45.4 |
Epileptic seizures | 51 | 39.2 |
Respiratory dysfunction | 49 | 37.7 |
Mental retardation | 48 | 36.9 |
Sucking dysfunction | 32 | 24.6 |
Hearing dysfunction | 25 | 19.2 |
Cardiac dysfunction | 23 | 17.7 |
Failure to thrive | 21 | 16.2 |
Hepatic dysfunction | 16 | 12.3 |
Microcephaly | 15 | 11.5 |
Peripheral neuropathy | 9 | 6.9 |
Renal dysfunction | 7 | 5.4 |
Haematological dysfunction | 2 | 1.5 |