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Table 1 Distributions used to model the 2011 birth-year Belgian cohort of haemophilia patients

From: The health and economic burden of haemophilia in Belgium: a rare, expensive and challenging disease

Parameter

Distribution

Reference

Incidence

Uniform (min = 1/5500, max = 1/4500)

Rosendaal and Briet[11]

Number of haemophilia A, haemophilia B cases

Dirichlet ({941, 212})

Belgian Haemophilia Association (year 2011)

Number of severe, moderate, mild haemophilia A cases

Dirichlet ({440.4, 180.7, 319.9})

Belgian Haemophilia Association (years 2006–2011)*

Number of severe, moderate, mild haemophilia B cases

Dirichlet({63.6, 63.6, 84.8})

Belgian Haemophilia Association (years 2006–2011)*

Standardized mortality rate

Beta-PERT (min = 0.8, mode = 1.4, max = 2.4)

Plug et al.[15]

  1. *The estimated number of severe, moderate and mild haemophilia cases was calculated using the mean number of new cases with haemophilia between 2006 and 2011 from the Belgian Haemophilia Association data; Dirichlet: Dirichlet distribution; Beta-PERT: Beta-PERT distribution.
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Orphanet Journal of Rare Diseases

ISSN: 1750-1172