Table 3 Major clinical features of the NK-cell lymphoma, nasal type, andaggressive NK-cell leukemia
From: Aggressive mature natural killer cell neoplasms: from epidemiology todiagnosis
Clinical features | NKTCL (nasal) | NKTCL (extranasal) | ANKCL |
|---|---|---|---|
Gender | Males > Females | Males > Females | Males = Females |
Age (years) | 50 – 60 | 50 – 60 | 30 – 40 |
Sites primarily involved | Nose, paranasal sinuses, orbits | Skin, gastrointestinal tract, salivary glands, lungs,eyes, soft tissues, adrenal glands, brain, breast, tong,other organs and tissues; rarely lymph nodes. | Blood, bone marrow, spleen, liver, lymph nodes |
Clinical presentation | Nasal bleeding, nasal obstruction, palate perforation,mid-facial and/or upper airway destructive lesions | Ulcers, masses | Fever, jaundice, splenomegaly, hepatomegaly,lymphadenopathy, cytopenias, hemophagocytic syndrome |
Prognosis | Early stages (I/II): good | Usually advanced stages (III/IV): poor | Highly aggressive / fatal |
| Â | Advanced stages (III/IV): poor | Â | Â |