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Table 3 Major clinical features of the NK-cell lymphoma, nasal type, andaggressive NK-cell leukemia

From: Aggressive mature natural killer cell neoplasms: from epidemiology todiagnosis

Clinical features NKTCL (nasal) NKTCL (extranasal) ANKCL
Gender Males > Females Males > Females Males = Females
Age (years) 50 – 60 50 – 60 30 – 40
Sites primarily involved Nose, paranasal sinuses, orbits Skin, gastrointestinal tract, salivary glands, lungs,eyes, soft tissues, adrenal glands, brain, breast, tong,other organs and tissues; rarely lymph nodes. Blood, bone marrow, spleen, liver, lymph nodes
Clinical presentation Nasal bleeding, nasal obstruction, palate perforation,mid-facial and/or upper airway destructive lesions Ulcers, masses Fever, jaundice, splenomegaly, hepatomegaly,lymphadenopathy, cytopenias, hemophagocytic syndrome
Prognosis Early stages (I/II): good Usually advanced stages (III/IV): poor Highly aggressive / fatal
  Advanced stages (III/IV): poor   
  1. Abbreviations: ANKTCL aggressive NK-cell leukemia,NKTCL NK/T-cell Lymphoma, nasal type.
  2. Adapted from [14].