Table 1 Summary of main effects of epitope-specific GAD65Ab on behavioral parameters measured in this study
Neurological evaluation | Morris water maze | ||||||
|---|---|---|---|---|---|---|---|
Total symptoms | Postural symptoms | Locomotor asymmetries | Complex behaviours | Escape latency | Total distance | Navigational strategies | |
7-b96.11 | Impairment (day1; p<0.03) | Impairment (day1; p<0.03) | Impairment (day1; p<0.03) | Impairment (day1, 3; p<0.03) | Increase (Cue; p<0.03) | Increase (Place1, Cue; p<0.03) | Circling Increase (Place1, Cue; p<0.001) |
5-b96.11 | Impairment (day1; p<0.03) | No Effect | No Effect | No Effect | No Effect | No Effect | No Effect |
7-b78 | Impairment (day1, 3, 4; p<0.03) | No Effect | No Effect | Impairment (day1, 3, 4; p<0.03) | No Effect | No Effect | No Effect |
5-b78 | No Effect | No Effect | No Effect | No Effect | No Effect | No Effect | No Effect |