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Table 1 Summary of main effects of epitope-specific GAD65Ab on behavioral parameters measured in this study

From: Monoclonal antibodies to 65kDa glutamate decarboxylase induce epitope specific effects on motor and cognitive functions in rats

  Neurological evaluation Morris water maze
  Total symptoms Postural symptoms Locomotor asymmetries Complex behaviours Escape latency Total distance Navigational strategies
7-b96.11 Impairment (day1; p<0.03) Impairment (day1; p<0.03) Impairment (day1; p<0.03) Impairment (day1, 3; p<0.03) Increase (Cue; p<0.03) Increase (Place1, Cue; p<0.03) Circling Increase (Place1, Cue; p<0.001)
5-b96.11 Impairment (day1; p<0.03) No Effect No Effect No Effect No Effect No Effect No Effect
7-b78 Impairment (day1, 3, 4; p<0.03) No Effect No Effect Impairment (day1, 3, 4; p<0.03) No Effect No Effect No Effect
5-b78 No Effect No Effect No Effect No Effect No Effect No Effect No Effect