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Table 2 Diagnostic criteria of LCH

From: Management of adult patients with Langerhans cell histiocytosis: recommendations from an expert panel on behalf of Euro-Histio-Net

Definitive: Presumptive (or compatible):
Based on clinic-pathological evidence with microscopic examination and at least one of the following immunological staining: Based only on clinico-radiological evidence, without biopsy, as in case of:
• Langerin (CD 207) positivity e.g.: Pulmonary lesions on CT scan with typical cysts and nodules in a smoker. (however, biopsy should be considered in order to reach a more definitive diagnosis)
• CD1a positivity
• Presence of Birbeck granules on electronic microscopy