Phenotypic characteristics of early Wolfram syndrome

Table 4 Neurologic exam findings

Subject	Motor	Deep_Tendon reflexes	Sensation	Coordination	Gait
WU.WOLF-01	Increased tone lower extremities; intention tremor	Brisk 3+/4 at ankles	Normal	Mild dysmetria	Unable to tandem walk
WU.WOLF-02	Normal	Normal	Normal	Normal	Normal
WU.WOLF-03	Normal	Normal	Impaired vibration (R6/L4)	Normal	Abnormal tandem walk
WU.WOLF-04	Fine finger movements slow; toe tapping slow	Normal	Impaired vibration (R4/L2)	Mild dysmetria (probably due to visual impairment)	Wide-based gait; unable to tandem walk
WU.WOLF-05	toe tapping slow	Normal	Normal	Normal	Abnormal tandem walk
WU.WOLF-07	Normal	Normal	Normal	Normal	Normal
WU.WOLF-09	Normal	Normal	Impaired vibration (R4/L4)	Normal	Abnormal tandem walk
WU.WOLF-10	Normal	Normal	Normal	Normal	Normal
WU.WOLF-11	Normal	Normal	Normal	Normal	Abnormal tandem walk
WU.WOLF-12	Normal	Normal	Impaired vibration (R2/L2)	Normal	Abnormal tandem walk
WU.WOLF-13	Normal	Normal	Normal	Normal	Normal
WU.WOLF-14	Fine finger movements slow	Normal	Normal	Normal	Normal
WU.WOLF-15	Normal	Normal	Normal	Normal	Normal
WU.WOLF-16	Normal	Normal	Mildly impaired vibration	Mild dysmetria	Abnormal tandem walk
WU.WOLF-17	Normal	Normal	Mildly impaired vibration	Some difficulty hopping	Abnormal tandem walk
WU.WOLF-18	Normal	Normal	Mildly impaired vibration	Normal	Mildly abnormal tandem walk
WU.WOLF-19	Normal	Normal	Difficult to assess, probably normal	Normal	Normal
WU.WOLF-22	Normal	Normal	Mildly impaired vibration	Normal	Normal

ISSN: 1750-1172