Skip to main content

Table 4 Neurologic exam findings

From: Phenotypic characteristics of early Wolfram syndrome

Subject Motor Deep_Tendon reflexes Sensation Coordination Gait
WU.WOLF-01 Increased tone lower extremities; intention tremor Brisk 3+/4 at ankles Normal Mild dysmetria Unable to tandem walk
WU.WOLF-02 Normal Normal Normal Normal Normal
WU.WOLF-03 Normal Normal Impaired vibration (R6/L4) Normal Abnormal tandem walk
WU.WOLF-04 Fine finger movements slow; toe tapping slow Normal Impaired vibration (R4/L2) Mild dysmetria (probably due to visual impairment) Wide-based gait; unable to tandem walk
WU.WOLF-05 toe tapping slow Normal Normal Normal Abnormal tandem walk
WU.WOLF-07 Normal Normal Normal Normal Normal
WU.WOLF-09 Normal Normal Impaired vibration (R4/L4) Normal Abnormal tandem walk
WU.WOLF-10 Normal Normal Normal Normal Normal
WU.WOLF-11 Normal Normal Normal Normal Abnormal tandem walk
WU.WOLF-12 Normal Normal Impaired vibration (R2/L2) Normal Abnormal tandem walk
WU.WOLF-13 Normal Normal Normal Normal Normal
WU.WOLF-14 Fine finger movements slow Normal Normal Normal Normal
WU.WOLF-15 Normal Normal Normal Normal Normal
WU.WOLF-16 Normal Normal Mildly impaired vibration Mild dysmetria Abnormal tandem walk
WU.WOLF-17 Normal Normal Mildly impaired vibration Some difficulty hopping Abnormal tandem walk
WU.WOLF-18 Normal Normal Mildly impaired vibration Normal Mildly abnormal tandem walk
WU.WOLF-19 Normal Normal Difficult to assess, probably normal Normal Normal
WU.WOLF-22 Normal Normal Mildly impaired vibration Normal Normal