Table 4 Univariate Cox proportional hazard model evaluating predictors for disease progression and the necessity of repeated WLL
From: Serum KL-6 is a predictor of outcome in pulmonary alveolar proteinosis
Variable | Hazard ratio | CI 95% | p value | |
|---|---|---|---|---|
Disease progression | Â | Â | Â | Â |
KL-6 U/mL (cont.) | 1.000 | 1.000 | 1.001 | 0.002 |
KL-6 ≥1526 U/mL (binary) | 6.284 | 1.767 | 22.352 | 0.005 |
Age, yrs (cont.) | 0.967 | 0.922 | 1.010 | 0.164 |
Gender (female=1) | 5.448 | 1.509 | 19.671 | 0.010 |
Smoking history (positive=1) | 27.203 | 0.087 | 8539.00 | 0.260 |
LDH IU/L (cont.) | 1.007 | 1.002 | 1.012 | 0.003 |
GM-CSF autoantibodies μg/mL (cont.) | 0.993 | 0.968 | 1.020 | 0.617 |
PaO2, mmHg (cont.) | 0.935 | 0.892 | 0.980 | 0.005 |
A-aDO2, mmHg (cont.) | 1.067 | 1.020 | 1.115 | 0.010 |
VC, % pred. (cont.) | 0.955 | 0.922 | 0.989 | 0.009 |
DLCO, % pred. (cont.) | 0.948 | 0.909 | 0.989 | 0.012 |
Necessity of repeated WLL | Â | Â | Â | Â |
KL-6 U/mL (cont.) | 1.000 | 1.000 | 1.000 | <0.001 |
KL-6 ≥2157 U/mL (binary) | 20.776 | 4.316 | 100.015 | <0.0001 |
Age, yrs (cont.) | 0.934 | 0.883 | 0.989 | 0.019 |
Gender (female=1) | 2.910 | 0.786 | 10.769 | 0.110 |
Smoking history (positive=1) | 28.329 | 0.060 | 13470.548 | 0.288 |
LDH, IU/L (cont.) | 1.010 | 1.004 | 1.017 | 0.001 |
GM-CSF autoantibodies, μg/mL (cont.) | 0.996 | 0.967 | 1.025 | 0.767 |
PaO2, mmHg (cont.) | 0.923 | 0.875 | 0.975 | 0.004 |
A-aDO2, mmHg (cont.) | 1.095 | 1.032 | 1.162 | 0.003 |
VC, % pred. (cont.) | 0.940 | 0.906 | 0.975 | 0.001 |
DLCO, % pred. (cont.) | 0.935 | 0.892 | 0.980 | 0.005 |