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Figure 3 | Orphanet Journal of Rare Diseases

Figure 3

From: Mucopolysaccharidosis type VI phenotypes-genotypes and antibody response to galsulfase

Figure 3

Antibody titer of patient 2 by immunoprecipitation. A fixed amount of galsulfase was incubated with serially diluted serum of patient 2. X-axis: 1/dilution factor (for example, 0.02 represents a dilution factor of 50). The antibody-bound galsulfase was precipitated using Protein A Sepharose beads, and the activity remaining in the supernatant was measured with paranitrocatecholdisulfate. The numbers at the right side of the curves represent the ERT duration in weeks (w) or years (y). The ELISA titers at these time points were 1:31,250 except at the 4y point (1:156,250). The open squares show the precipitation of galsulfase by rabbit anti-galsulfase serum; the open circles show the precipitation of a healthy individual (normal serum).

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