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Table 1 Characteristics of Primary Hyperparathyroidism in Sporadic, MEN1 and MEN2A Patients

From: Differences between sporadic and MEN related primary hyperparathyroidism; clinical expression, preoperative workup, operative strategy and follow-up

Characteristics Sporadic pHPT, n= 467 MEN1-pHPT, n= 52 MEN2A-pHPT, n= 16
Female, n 357 (76%) 33 (63%) 9 (56%)
Age, y, median (range) 63 (20 to 88) 33 (11 to 62) 39 (20 to 66)
Symptoms at first presentation, n 467 (100%) 42 (81%) 12 (75%)
 Fatigue 188 (40%) 16 (31%) 4 (25%)
 Renal stones 115 (25%) 14 (27%) 3 (19%)
 Osteoporosis 73 (16%) 0 4 (25%)
 Gastrointestinal symptoms 67 (14%) 7 (14%) 0
 Neuropsychiatric 42 (9%) 7 (14%) 1 (6%)
Preoperative serum level, mean (range)    
 Ionized calcium, mg/dL 6.76 (4.60 to 7.40) 5.56 (4.44 to 6.44) 5.4 (5.32 to 5.68)
 Calcium, mg/dL 11.56 (10.12 to 22.20) - -
 Parathyroid hormone, pg/mL 219 (10 to 3097) 78 (16 to 191) 89 (52 to 249)
Imaging modality, n    
 Ultrasonography 399 (85%) 30 (57%) 10 (63%)
 Computed tomography 317 (68%) 13 (25%) 8 (50%)
Technetium-99m-sestamibi-scintigraphy 206 (44%) 12 (23%) 8 (50%)
Number of used imaging modalities, mean 1.97 1.06 1.63
  1. Abbreviations: pHPT, primary hyperparathyroidism; MEN1, multiple endocrine neoplasia type 1; MEN2A, multiple endocrine neoplasia type 2A.