Table 1 Characteristics of Primary Hyperparathyroidism in Sporadic, MEN1 and MEN2A Patients
Characteristics | Sporadic pHPT, n= 467 | MEN1-pHPT, n= 52 | MEN2A-pHPT, n= 16 |
|---|---|---|---|
Female, n | 357 (76%) | 33 (63%) | 9 (56%) |
Age, y, median (range) | 63 (20 to 88) | 33 (11 to 62) | 39 (20 to 66) |
Symptoms at first presentation, n | 467 (100%) | 42 (81%) | 12 (75%) |
 Fatigue | 188 (40%) | 16 (31%) | 4 (25%) |
 Renal stones | 115 (25%) | 14 (27%) | 3 (19%) |
 Osteoporosis | 73 (16%) | 0 | 4 (25%) |
 Gastrointestinal symptoms | 67 (14%) | 7 (14%) | 0 |
 Neuropsychiatric | 42 (9%) | 7 (14%) | 1 (6%) |
Preoperative serum level, mean (range) | Â | Â | Â |
 Ionized calcium, mg/dL | 6.76 (4.60 to 7.40) | 5.56 (4.44 to 6.44) | 5.4 (5.32 to 5.68) |
 Calcium, mg/dL | 11.56 (10.12 to 22.20) | - | - |
 Parathyroid hormone, pg/mL | 219 (10 to 3097) | 78 (16 to 191) | 89 (52 to 249) |
Imaging modality, n | Â | Â | Â |
 Ultrasonography | 399 (85%) | 30 (57%) | 10 (63%) |
 Computed tomography | 317 (68%) | 13 (25%) | 8 (50%) |
Technetium-99m-sestamibi-scintigraphy | 206 (44%) | 12 (23%) | 8 (50%) |
Number of used imaging modalities, mean | 1.97 | 1.06 | 1.63 |