Skip to main content

Table 3 Identification of key MMD-associated target genes

From: Immune response profiling identifies autoantibodies specific to Moyamoya patients

Proteins Enriched p value Function ProtoArray p value DER * Chromosomal location
APP < 0.02 Increased risk of hemorrhagic stroke, Alzheimer disease pathogenesis, DDR [4042] 0.029 0.604 21q21.3
CTNNB1 0.01 Regulation of neural progenitor cell cycle, Wnt signaling in carcinoma/angiogenesis, chromosome instability [4345] 0.0197 0.555 3p21
EDIL3 0.01 Role in angiogenesis and vessel wall remodeling and development [46, 47] 0.0003 0.484 5q14
ROR1 0.01 Possible role in cell migration and remodeling of cytoskeleton [48] 0.0029 0.586 1p32-p31
GPS1 0.02 Component of the COP9 signalosome, DDR [49] 0.07 0.46 17q25.3
STRA13 0.01 Component of the FA protein complex, DDR, component of the kinetocore [5052] 0.0021 0.581 17q25.3
  1. MMD-specific target proteins were identified through functional interpolating SNPs approach (fitSNPs), a bioinformatics method that integrates antibodyomic, genetic, and genomic data.
  2. * DER = fitSNP differential expression ratio.