Skip to main content
Figure 6 | Orphanet Journal of Rare Diseases

Figure 6

From: Brain damage in methylmalonic aciduria: 2-methylcitrate induces cerebral ammonium accumulation and apoptosis in 3D organotypic brain cell cultures

Figure 6

Effects of 2-MCA, MMA and PA on ammonium and glutamine levels. Ammonium (A and C) and glutamine (B and D) were measured in the medium of cultures from DIV 8 and DIV 14. Cultures were exposed to 1 mM 2-MCA, MMA or PA (A and B) or lower concentrations of 2-MCA (C and D). Mean ± SEM of 4 to 7 replicate cultures assessed by Student’s t-test; *p<0.05, **p<0.01, *** p<0.001.

Back to article page

Orphanet Journal of Rare Diseases

ISSN: 1750-1172