Passive transfer of collagen XVII-specific antibodies induces sustained blistering disease in adult mice

Table 1 Antibodies to the dermal-epidermal junction (DEJ) produced for this study

Serum	Species	Molecular target^a	IF^b	CBT^c
R1-mCXVII	Rabbit	BP180/ CXVII	2560	+
R2-mCXVII	Rabbit	BP180/ CXVII	640	+
R3-mCXVII	Rabbit	BP180/ CXVII	1280	+
S1-mCXVII	Sheep	BP180/ CXVII	20480	+

^a antibodies were elicited against a mixture of BP180/ CXVII fragments (see methods).
^b titre of indirect immunofluorescence (IF) microscopy on mouse skin sections.
^c C3 deposition at the DEJ of mouse skin by the complement binding test (CBT).

ISSN: 1750-1172