Skip to main content

Table 3 Nerve conduction studies in genetically defined subtypes of HSP

From: Electrophysiological characterisation of motor and sensory tracts in patients with hereditary spastic paraplegia (HSP)

Genotype Tibial nerve Ulnar nerve Sural nerve Radial nerve
  DML (in ms) CMAP (in mV) MNCV (in m/s) FWL (in ms) DML (in ms) CMAP (in mV) MNCV (in m/s) FWL (in ms) SNAP (in μV) SNCV (in m/s) SNAP (in μV) SNCV (in m/s)
SPG3 0/1 0/1 0/1 0/1 0/1 0/1 0/1 0/1 0/1 0/1 0/1 0/1
3.6 14.6 52 48.8 2.2 10.1 61 28 24.0 57 20.3 57
SPG4 6/35 0/35 2/35 1/35 1/34 0/34 1/34 1/34 4/35 6/35 5/29 2/29
4.3±0.8 18.7±6.8 47.2±5.7 51.7±4.9 2.4±0.4 15.9±3.2 60.8±4.5 27.6±2.3 11.1±7.8 47.7±7.0 22.2±7.0 62.0±5.0
3.0-6.5 7.3-35.0 36-69 43.0-66.3 1.7-3.2 6.8-22.7 50-69 23.2-33.7 0–37.7 34-64 10.9-35.2 50-73
SPG5 0/3 0/3 0/3 0/3 1/3 0/3 0/3 0/3 0/3 0/3 0/3 0/3
3.8±0.9 26.6±11.0 46.0±5.0 48.7±6.5 2.8±0.6 15.5±4.4 66.7±3.2 24.3±2.7 28.7±13.1 46.7±8.1 32.9±2.6 64.3±4.2
2.9-4.7 17.3-38.7 41-51 41.2-53.0 2.1-3.3 12.8-20.5 63-69 21.6-27.0 14.6-40.5 41-56 30.6-35.7 61-69
SPG7 0/3 0/3 0/3 0/3 0/3 0/3 0/3 0/3 0/3 0/3 0/3 0/3
4.0±0.4 22.1±9.1 46.7±3.5 47.5±5.7 2.2±0.3 15.1±4.0 65.7±1.5 28.8±0.3 17.5±4.9 48.7±2.3 24.0±2.4 63.7±2.5
3.7-4.5 11.7-28.3 43-50 41.2-52.4 1.8-2.4 12.3-19.7 64-67 28.4-29.0 12.9-22.6 46-50 21.9-26.6 61-66
SPG8 0/1 0/1 1/1 0/1 0/1 0/1 0/1 0/1 0/1 0/1 0/1 0/1
3.2 10.2 37 54.3 2.4 16.1 59 28.3 26.0 43 19.7 59
SPG10 0/1 0/1 1/1 0/1 0/1 0/1 0/1 0/1 0/1 0/1 0/1 0/1
4.2 22.1 40 51.4 2.5 11.4 51 27.2 5.9 52 23.1 61
SPG11 1/6 1/6 3/6 1/5 1/6 2/6 0/6 1/5 1/6 1/6 2/5 3/5
4.7±2.1 18.6±12.2 41.7±3.6 51.9±7.6 2.9±0.7 14.0±7.1 61.5±4.3 27.6±2.0 12.1±10.9 47.0±5.8 19.2±5.6 55.0±4.4
3.6-8.8 0.9-36.1 37-46 45.1-64.8 2.1-4.3 1.1-21.1 58-70 24.6-29.0 1.6-31.6 38-56 12.5-24.5 48-60
SPG15 0/4 0/4 3/4 0/4 0/4 0/4 0/4 2/4 1/4 1/4 1/3 1/3
4.3±1.0 8.8±3.8 38.3±5.7 56.9±5.4 2.7±0.2 14.2±2.3 55.3±4.6 30.3±2.8 7.1±3.7 47.5±13.9 18.6±6.0 56.3±2.9
2.8-5.0 5.8-14.3 30-43 49.0-61.0 2.4-2.8 11.6-16.4 51-61 26.1-32.2 2.9-11.9 31-65 11.7-22.4 53-58
Threshold value < 5.1 > 5.0 > 40 < 63.6 < 3.2 > 4.0 > 50 < 31.0 > 3.8 > 39 > 16.0 > 55
  1. For each genotype is given: in the first row the number of pathologic results in the number of individuals examined, in the second row mean and standard deviation, and in the third row the range of values. DML: distal motor latency, CMAP: compound motor action potential, MNCV: mean nerve conduction velocity, FWL: F wave latency, SNAP: sensory nerve action potential, SNCV: sensory nerve conduction velocity.