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Table 2 Transcranial magnetic stimulation and sensory evoked potentials in genetically defined subtypes of HSP

From: Electrophysiological characterisation of motor and sensory tracts in patients with hereditary spastic paraplegia (HSP)

Genotype CMCT ADM (in ms) CMCT AH (in ms) N20 latency (in ms) P40 latency (in ms)
SPG3 0/1 1/1 n.d. n.d.
6.4 29.0   
SPG4 0/35 17/35 0/12 6/24
5.1 ± 1.4 14.1 ± 3.9 19.9 ± 1.1 42.6 ± 3.6
3.0-8.4 7.0-23.0 18.0-21.8 37.8-52.6
SPG5 1/3 3/3 2/2 2/2
7.8 ± 2.5 24.4 ± 5.5 - -
5.2-10.6 19.0-29.0 - -
SPG7 0/3 2/3 0/1 1/2
4.4 ± 1.5 18.6 ± 6.5 20.9 46.3 ± 3.0
2.4-6.4 13.8-25.6 - 42.8-49.6
SPG8 1/1 1/1 0/1 1/1
- - 19.3 49.7
SPG10 0/1 1/1 0/1 1/1
3.9 - 19.0 -
SPG11 1/6 4/6 0/2 2/4
4.9 ± 1.0 13.3 ± 1.4 20.0 ± 0.6 43.2 ± 0.7
3.6-6.0 12.0-15.2 19.0-20.5 42.0-44.6
SPG15 3/4 4/4 n.d. 1/1
7.6 ± 2.4 -   50.8
4.4-10.2 -   -
Threshold value < 8.6 < 16.0 < 23.3 < 49.0
  1. For each genotype is given: in the first row the number of pathologic results in the number of individuals examined, in the second row mean and standard deviation, and in the third row the range of values. CMCT: central motor conduction time, ADM: abductor digiti minimi, AH: abductor hallucis, N20: primary cortical negativity of somatosensory potentials with median nerve stimulation, P40: primary cortical positivity of somatosensory potentials with tibial nerve stimulation, n.d.: not done.