Table 2 Transcranial magnetic stimulation and sensory evoked potentials in genetically defined subtypes of HSP
Genotype | CMCT ADM (in ms) | CMCT AH (in ms) | N20 latency (in ms) | P40 latency (in ms) |
|---|---|---|---|---|
SPG3 | 0/1 | 1/1 | n.d. | n.d. |
6.4 | 29.0 | |||
SPG4 | 0/35 | 17/35 | 0/12 | 6/24 |
5.1 ± 1.4 | 14.1 ± 3.9 | 19.9 ± 1.1 | 42.6 ± 3.6 | |
3.0-8.4 | 7.0-23.0 | 18.0-21.8 | 37.8-52.6 | |
SPG5 | 1/3 | 3/3 | 2/2 | 2/2 |
7.8 ± 2.5 | 24.4 ± 5.5 | - | - | |
5.2-10.6 | 19.0-29.0 | - | - | |
SPG7 | 0/3 | 2/3 | 0/1 | 1/2 |
4.4 ± 1.5 | 18.6 ± 6.5 | 20.9 | 46.3 ± 3.0 | |
2.4-6.4 | 13.8-25.6 | - | 42.8-49.6 | |
SPG8 | 1/1 | 1/1 | 0/1 | 1/1 |
- | - | 19.3 | 49.7 | |
SPG10 | 0/1 | 1/1 | 0/1 | 1/1 |
3.9 | - | 19.0 | - | |
SPG11 | 1/6 | 4/6 | 0/2 | 2/4 |
4.9 ± 1.0 | 13.3 ± 1.4 | 20.0 ± 0.6 | 43.2 ± 0.7 | |
3.6-6.0 | 12.0-15.2 | 19.0-20.5 | 42.0-44.6 | |
SPG15 | 3/4 | 4/4 | n.d. | 1/1 |
7.6 ± 2.4 | - | 50.8 | ||
4.4-10.2 | - | - | ||
Threshold value | < 8.6 | < 16.0 | < 23.3 | < 49.0 |