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Figure 1 | Orphanet Journal of Rare Diseases

Figure 1

From: ACTH-independent macronodular adrenocortical hyperplasia reveals prevalent aberrant in vivo and in vitroresponses to hormonal stimuli and coupling of arginine-vasopressin type 1a receptor to 11β-hydroxylase

Figure 1

In vivo and in vitro induction of cortisol production following administration of hormonal stimuli. (A) Patients were tested for the presence of aberrant expression of eutopic or ectopic hormone receptors by the administration of hormonal stimuli in various tests indicated on the X-axis. Line represents mean. *p<0.05, **p<0.01, ***p<0.001 compared to basal level (Wilcoxon signed rank test). (B) Primary cell cultures from AIMAH tissues (white bars) or from normal adrenals, ACTH-dependent adrenocortical hyperplasia or adenomas (other, black bars) were incubated for 2 h in the presence of specific hormone receptor agonists indicated on the X-axis. Concentrations used have been summarized in Table 3. Data are represented as mean+SEM. *p<0.05, **p<0.01, ***p<0.001 compared to vehicle control (Wilcoxon signed rank) or between pathological entities (Mann–Whitney U test). (C) Cortisol induction in media of AIMAH or other adrenal cells after 48 h incubation with specific hormone receptor agonists. Concentrations used are summarized in Table 4. Data are represented as mean+SEM. *p<0.05 compared to vehicle control (Wilcoxon signed rank). Numbers of patients are shown in Tables 2, 3 and 4.

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Orphanet Journal of Rare Diseases

ISSN: 1750-1172