Figure 3From: A mutation in the serine protease TMPRSS4 in a novel pediatric neurodegenerative disorderGenetic investigations to find the causative mutation for ARCA. A) Variant filtration of exome sequencing data of two affected individuals, V-10 and V-12. Non-synonymous is defined as a change that alters the amino acid. B) Homozygosity mapping narrows candidate region to 11q23.3, containing 91 genes.Back to article page