Skip to main content
Figure 4 | Orphanet Journal of Rare Diseases

Figure 4

From: Compounds that correct F508del-CFTR trafficking can also correct other protein trafficking diseases: an in vitro study using cell lines

Figure 4

Few F508del-CFTR correctors correct the trafficking of hERG F805C. (A) A representative immunoblot is shown for cells transfected with vector control (vector), wt hERG (wt), and hERG F805C treated with negative control (DMSO), positive control (DMSO 29°C), astemizole, VRT-325, decreasing concentrations of KM60, KM57, and ouabain (ouab). Arrows indicate core and complex-glycosylated hERG F805C. Tubulin is shown as a loading control. (B) A representative immunoblot is shown for cells transfected with vector control (vector), wt hERG (wt), and hERG F805C treated with negative control (DMSO), positive control (DMSO 29°C), astemizole, VRT-325, decreasing concentrations of RDR1 and glafenine. Arrows indicate core and complex-glycosylated hERG F805C. Tubulin is shown as a loading control.

Back to article page

Orphanet Journal of Rare Diseases

ISSN: 1750-1172