Early presentation of gait impairment in Wolfram Syndrome

Table 2 Main effects of group and task and two-way interactions

		Cadence (steps/min)	p-value	Normed Velocity	p-value	Step Extremity Ratio	p-value	Normed Base of Support	p-value	% Double Support	p-value
group	WFS	124.4 ± 4.4	= 0.620	1.7 ± 0.08	* = 0.028	0.82 ± 0.02	** < 0.001	8.2 ± 0.5	** = 0.001	20.0 ± 0.9	** = 0.003
group	TD	127.1 ± 2.9	= 0.620	2.0 ± 0.06	* = 0.028	0.91 ± 0.01	** < 0.001	5.8 ± 0.4	** = 0.001	16.5 ± 0.6	** = 0.003
task	FP	121.3 ± 13.7	** ≤ 0.001	1.9 ± 0.38	** ≤ 0.001	0.92 ± 0.02	** ≤ 0.001	6.1 ± 0.3	** ≤ 0.001	17.9 ± 0.6	** ≤ 0.001
	FF	157.2 ± 22.4		2.9 ± 0.52		1.09 ± 0.02		6.2 ± 0.3		14.3 ± 0.6
	FD	110.2 ± 13.8		1.5 ± 0.29		0.82 ± 0.01		5.9 ± 0.5		19.9 ± 0.7
	BP	116.3 ± 20.0		1.3 ± 0.31		0.62 ± 0.02		9.9 ± 0.5		20.9 ± 0.6
		group x task
WFS	FP	120.5 ± 11.4	= 0.936	1.8 ± 0.30	= 0.604	0.89 ± 0.03	= 0.603	7.2 ± 0.6	= 0.948	19.2 ± 1.0	= 0.462
	FF	154.0 ± 16.9		2.7 ± 0.48		1.04 ± 0.03		7.3 ± 0.6		16.0 ± 1.1
	FD	108.8 ± 12.2		1.4 ± 0.26		0.78 ± 0.02		7.2 ± 0.8		22.1 ± 1.2
	BP	114.4 ± 16.8		1.1 ± 0.34		0.56 ± 0.03		11.2 ± 0.9		22.8 ± 1.1
TD	FP	121.7 ± 14.7		2.0 ± 0.41		0.96 ± 0.02		5.1 ± 0.4		16.6 ± 0.6
	FF	158.6 ± 24.6		3.0 ± 0.51		1.14 ± 0.02		5.0 ± 0.4		12.7 ± 0.7
	FD	110.9 ± 14.6		1.6 ± 0.29		0.86 ± 0.01		4.6 ± 0.5		17.7 ± 0.8
	BP	117.1 ± 21.5		1.3 ± 0.28		0.68 ± 0.02		8.6 ± 0.6		19.0 ± 0.7

WFS = individuals with Wolfram syndrome; TD = typically developing individuals; FP = forward preferred; FF = forward fast; FD = forward dual task; and BP = backward preferred.
Values are means ± SD.
* denotes significant correlation at the 0.05 level.
** denotes significant correlation at the 0.01 level.

ISSN: 1750-1172