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Table 4 Bivariate associations of type of ART with risk of ARM

From: Assisted reproductive techniques and the risk of anorectal malformations: a German case-control study

Group

 

Population-based controls N (%)

All ARM cases

Prospectively collected ARM cases in 2009 to 2011

   

N (%)

OR (95% CI)

P value

N (%)

OR (95% CI)

P value

ART

No

9,940,004 (99%)

265 (90%)

1.0 (Reference)

-

121 (90%)

1.0 (Reference)

-

 

IVF

44,844 (0.4%)

13 (4%)

10.9 (6.2–19.0)

<0.0001

6 (4%)

11.0 (4.8–25.0)

<0.0001

 

ICSI

85,138 (0.9%)

17 (6%)

7.5 (4.6–12.2)

<0.0001

8 (6%)

7.7 (3.8–15.8)

<0.0001

  1. ART = assisted reproductive techniques, OR = odds ratio, CI = confidence interval.
  2. IVF = in-vitro fertilization, ICSI = intracytoplasmic sperm injection.