| CCALD | AdolCALD | ACALD | AMN | Addison only | Women with X-ALD | |
---|---|---|---|---|---|---|---|
No cerebral disease | Cerebral disease | ||||||
Frequency (%) | 31 - 35 | 4 - 7 | 2 - 5 | 40 - 46 | 20% of AMN patients over a period of 10 years | Decreasing with age | unknown how many are symptomatic |
Age at onset | 2.5 - 10 | 10 - 21 | > 21 | > 18 | > 18 | > 2 | highly variable, mostly > 40 |
Myelopathy | - | Possible at a preclinical stage | + or - | + | + | - | + |
White matter lesions on brain MRI | Extensive | Extensive | Extensive | Wallerian degeneration of the | parieto-occipital, frontal, or | - | Very rare |
 |  |  |  | corticospinal tracts in brain-stem, pons and internal capsules | involving the centrum semiovale |  | Wallerian degeneration of the corticospinal tracts in brain-stem, pons and internal capsules is less common than in males with AMN |
Behavioral and cognitive disorder | + | + | + | - | + | - | Very rare |
Peripheral neuropathy | - | rare | possible | Sensory-motor, mostly axonal, rarely demyelinating | Sensory-motor, mostly axonal | - | +/− |
Endocrine disorder | often AD | often AD | often AD | often AD and testicular insufficiency | often AD and testicular insufficiency | AD | AD rare (< 1%) |
Progression | rapid | rapid | rapid | slow | rapid | - | slow |