|
Characteristic
| |
|---|
|
Cases
| |
|
Number
|
371
|
|
FSH concentration (IU/L)a
|
73.88 ± 30.23
|
|
Familial clusteringb
|
32
|
|
Mother affected
|
27
|
|
Menopause < 40 yrs
|
13
|
|
40 yrs < Menopause < 45 yrs
|
14
|
|
Siblings affected
|
5
|
|
Menopause < 40 yrs
|
5
|
|
Age at diagnosis (yrs)a
|
29.79 ± 5.31
|
|
Amenorrhea Secondary
|
228
|
|
Age at menarche (yrs)a
|
14.82 ± 2.11
|
|
Age at onset of menstrual dysfunction (yrs)a
|
23.85 ± 6.78
|
|
Age at amenorrhea (yrs)a
|
24.87 ± 5.88
|
|
Controls
| |
|
Number
|
800
|
|
Age(yrs)a at sample
|
38.77 ± 11.58
|
|
Age at menarche(yrs)a
|
14.75 ± 1.45
|
- a ± SD
- b Defined as two or more first-or second-degree female family members with either POF or early menopause (less than 45 years old), including the index POF patient.
