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Table 1 Clinical features of cases and controls, which are not significantly different (p > 0.05).

From: ESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure

Characteristic  
Cases  
   Number 371
   FSH concentration (IU/L)a 73.88 ± 30.23
   Familial clusteringb 32
Mother affected 27
Menopause < 40 yrs 13
40 yrs < Menopause < 45 yrs 14
Siblings affected 5
Menopause < 40 yrs 5
   Age at diagnosis (yrs)a 29.79 ± 5.31
Amenorrhea Secondary 228
Age at menarche (yrs)a 14.82 ± 2.11
Age at onset of menstrual dysfunction (yrs)a 23.85 ± 6.78
Age at amenorrhea (yrs)a 24.87 ± 5.88
Controls  
   Number 800
   Age(yrs)a at sample 38.77 ± 11.58
   Age at menarche(yrs)a 14.75 ± 1.45
  1. a ± SD
  2. b Defined as two or more first-or second-degree female family members with either POF or early menopause (less than 45 years old), including the index POF patient.