ESR1, HK3 and BRSK1 gene variants are associated with both age at natural menopause and premature ovarian failure

Table 1 Clinical features of cases and controls, which are not significantly different (p > 0.05).

Characteristic
Cases
Number	371
FSH concentration (IU/L)^a	73.88 ± 30.23
Familial clustering^b	32
Mother affected	27
Menopause < 40 yrs	13
40 yrs < Menopause < 45 yrs	14
Siblings affected	5
Menopause < 40 yrs	5
Age at diagnosis (yrs)^a	29.79 ± 5.31
Amenorrhea Secondary	228
Age at menarche (yrs)^a	14.82 ± 2.11
Age at onset of menstrual dysfunction (yrs)^a	23.85 ± 6.78
Age at amenorrhea (yrs)^a	24.87 ± 5.88
Controls
Number	800
Age(yrs)^a at sample	38.77 ± 11.58
Age at menarche(yrs)^a	14.75 ± 1.45

^a ± SD
^b Defined as two or more first-or second-degree female family members with either POF or early menopause (less than 45 years old), including the index POF patient.

ISSN: 1750-1172