(Panel A: Index patients; Panel B: Non-index patients). Twenty-two patients suffered from severe complications before attainment of HHT definite diagnosis. Each horizontal bar represents one given patient - identified by a number on Y-axis - who suffered from AVM-related complications over the time of Diagnosis Time Lag (DTL). In X-axis the time before clinical onset is shown by a white dashed bar. The time comprised between clinical onset and attainment of definite diagnosis of HHT (corresponding to DTL) is shown by a grey full bar. For each patient, the first referral to a physician is labeled by a black vertical rod. Star-shaped markers indicate complication events: BA = Brain Abscess; BS = Brain Stroke; TIA = Transient Ischemic Attack; ICH = Intracranial Haemorrhage; PRH = Pulmonary Haemorrhage; GRH = Haemorrhage from Large Gastrointestinal Colonic AVM; SZ = Seizures; HOF = High-Output Heart Failure; LINS = Liver Insufficiency; OLTx = Orthotopic Liver Transplantation.