Table 2 Validation of the genes in the stage II, independent population of 106 trios
Gene | SNP | Allele | Transmited | Untransmited | Statistic and p-value |
|---|---|---|---|---|---|
RASGEF1A (rs1254964 p = 3.856x10 -05 ) | rs1254958 | G | 143 (67.45%) | 187 (88.2%) | χ 2 = 25.27; p = 5x10-7 |
A | 69 (35.55%) | 25 (11.8%) | |||
rs10793422 | G | 141 (66.5%) | 184 (86.8%) | χ 2 = 23.25; p = 1.4 x10-6 | |
A | 71 (33.5%) | 28 (13.2%) | |||
rs2503846 | T | 32 (15.0%) | 71 (33.5%) | χ 2 = 18.52; p = 1.68x10-5 | |
G | 180 (85.0%) | 141 (66.5%) | |||
IQGAP2 (rs950643 p = 0.0003585) | rs3797412 | A | 146 (68.8%) | 179 (84.4%) | χ 2 = 13.49; p = 2.393x10-4 |
G | 66 (31.2%) | 33 (15.6%) | |||
DLC1 (rs1454947 p = 0.007526) | rs9325866 | T | 34 (16.0%) | 52 (24.5%) | χ 2 = 4.22; p = 0.0401 |
C | 178 (8.04%) | 160 (75.5%) | |||
rs536147 | T | 36 (16.9%) | 56 (24.5%) | χ2 = 5.00; p = 0.0252 | |
C | 176 (83.1%) | 156 (75.5%) | |||
CHRNA7 (rs2175886 p = 0.000607) | rs868437 | C | 47 (22.2%) | 76 (35.8%) | χ 2 = 8.98; p = 0.0027 |
T | 165 (77.8%) | 136 (64.2%) |