Table 4 Chemotherapy regimens used in the treatment of SCCB
From: A rare bladder cancer - small cell carcinoma: review and update
Regimen | Schedule | Drugs and doses | ||||
|---|---|---|---|---|---|---|
First line | ||||||
On day 1 to 3, repeated after 21 days | Etoposide 120 mg/m2 on day 1 to 3 | Cisplatin 80-100 mg/m2 , on day 1 | Â | Â | Â | |
Alternative regimen: ifosfamide plus doxorubicin on day 1 to 3 repeated every 42 days and etoposide plus cisplatin on day 22 to 26 repeated after 42 days | Ifosfamide 2 g/m2 , on day 1 to 3 | Doxorubicin 25 mg/m2 , on day 1 to 3 | Etoposide 80 mg/m2 , on day 22 to 26 | Cisplatin 20 mg/m2 , on day 22 to 26 | Â | |
VIP (IV)[10] | On day 1 to 4, repeated after 21 days | Ifosfamide 1.2 g/m2 , on day 1 to 4 | Etoposide 75 mg/m2 on day 1 to 4 | Cisplatin 20 mg/m2 on day 1 to 4 | Â | Â |
EP/CAV (IV)[11] | Alternative regimen: EP on day 1 to 3 repeated after 42 days and CAV on day 22 repeated every 42 days | Etoposide 100 mg/m2 on day 1 to 3 | Cisplatin 80 mg/m2 , on day 1 | Cyclophosphamide 800 mg/m2 on day 22 | Doxorubicine 50 mg/m2 on day 22 | Vincristine 1.4 mg/m2 on day 22 |
MVAC (IV)[12] | On day 1, 2, 15, and 22, repeated every 28 days | Methotrexate 30 mg/m2 on day 1, 15 and 22 | Vinblastine 3 mg/m2 on day 2, 15, and 22 | Doxorubicin 30 mg/m2 on day 2 | Cispatin 70 mg/m2 on day 2 | Â |
Second line | ||||||
Topotecan (IV)[5] | On day 1 to 5, repeated every 21 days | Topotecan 1.5 mg/m2 on day 1 to 5 | Â | Â | Â | Â |
CAV (IV) | On day 1, repeated every 21 days | Cyclophosphamide 800 mg/m2 on day 1 | Doxorubicin 50 mg/m2 on day 1 | Vincristine 1.4 mg/m2 on day 1 | Â | Â |
Vinorelbine (IV)[41] | On day 1, 8, and 15. The cycle is repeated every 21 days | Vinorelbine 25 mg/m2 on day 1, 8, and 15 | Â | Â | Â | Â |